The Iodine Project

Treating symptoms, not masking them.

So is Fluoride Good or Bad?

To answer your question in short, bad, very bad.

Here is what happened to my family over the course of a year following the fluoridation of our water...

My husband grew a goiter and went from hypo to hyper with constant anxiety attacks, my mother has had sever migraines over the past year (they used to be a few times a month now they have been a few times a week), my sisters asthma was nearly gone and since the fluoridation she has had to use an inhaler nearly every day, my nephew has become more aggressive (he's 5), my son started having bouts of crying fits for no apparent reason (he's also 5), I had just become pregnant when they fluoridated and the pregnancy combined with the fluoridation zapped my iodine levels leaving me sleeping in bed most of the day throughout my pregnancy and developed anemia shortly after delivery despite how little I bled (have read some links between iodine deficiency and low iron), I also have suffered from frequent and severe headaches.

 Informational video on Fluoride: history and toxicity

 Part 2    Part 3


Here is what  Charles Weber had to say... 



By Charles Weber (I recommend that you seek a second opinion on any medical problems from competent professionals before making any substantive changes in any of your procedures.)

----Fluoride has been added to water in the form of hexafluorosilicic acid (an industrial waste product) in the hope that it would reduce tooth decay. However it is a poison that has some serious side effects, badly affecting almost every organ in the body and does not reduce tooth decay in permanent teeth (has graphs) nor even in first teeth. Europe is only 2% fluoridated but has tooth decay similar to or less than ours. It is more poisonous than lead and only marginally less so than arsenic.
----The side effect that is the most obvious is a discoloration of the teeth called fluorosis (includes treatments) [Pendrys]. This is inevitable if the dose of fluoride is only a little over optimum. This is very easy to happen to anyone who drinks a lot of water, say for kidney problems or for baby formula. It is also likely if someone eats or drinks food high in fluoride such as tea [Gulati], coffee, reconstituted fruit juice, grapes or raisins that have had fluoride insecticide (cryolite), dried eggs, and carbonated drinks. Fagin gives fluoride content of some foods [Fagin]. While the fluorosis effect is fairly trivial other than appearance, the cost of correcting it can be as much as $15,000. This cost should be made good by the water companies and insecticide manufacturers.
---- Fluorides cause premature aging of the human body [Leone] [Erikson].
----A more serious effect is irreversible bone deformation [Fagin, with pictures] [Reddy] and increases of bone fractures [Orcel]. The affects on bone can mimic some of the symptoms of arthritis. Fluoride interferes with the hydroxylation of proline to hydroxyproline [Sharma]. Therefore fluoride exposure disrupts the synthesis of collagen and leads to the breakdown of collagen in bone, tendon, muscle, skin, cartilage, lungs, kidney, trachea and arteries. [Susheela and Mukerjee] - the type of damage you'd expect to see in connective tissue disorders. It will also cause damage to ligaments resembling arthritis.
----An even more serious effect is bone cancer in young boys, but for some strange reason, not girls. During the growth spurt during 6 to 8 years the bone cancer rate is 8 times higher in boys living in fluoridated areas than in non poisoned water areas [Bassin]. Fluoride confuses the immune system and causes it to attack the body's own tissues, and increases the tumor growth rate in cancer prone individuals [Taylor]. There is 1963 increased Incidence of Melanotic Tumors Following Treatment with Sodium Fluoride [Herskowitz]. In view of this adding fluoride to water is breaking the former Delaney amendment law prohibiting adding cancer causing chemicals to food. That law should be reestablished.
----Proteins are kept in their three dimensional structure by weak bonds between adjacent proteins called hydrogen bonds. Emsley, et al found that fluoride disrupts this hydrogen bonding within proteins by virtue of an unusually strong bond between fluoride ion and the NH group of amides [Emsley]. In other words, it changes some associated proteins and enzymes from the exact shape they’re suppose to be in. It also reduces the ability of white blood cells to kill pathogens [Weisman].
---- Fluoride depresses Thyroid activity [Von Mundy] [Galleti]. Fluoride and bromide block the uptake and utilization of iodine in target cells [Abraham 2004]. Fluoride has been proposed to inhibit the thyroid and fluoride symptoms have many similarities to low thyroid. Children in India who had fluoride in their blood had thyroid abnormality. Fluoride has been found to cause goiter in South Africa. A government-sponsored report has concluded that levels of fluoride that people are regularly exposed to in drinking water can cause serious malfunctioning of the thyroid gland, leading to even more serious health problems. The thyroid requires l-tyrosine to make the hormone, so supplements of this amino acid may be helpful.
---- I now have to take thyroid hormone, so I have a personal reason for resenting adding this poison to my drinking water, for it is highly probable that fluoride is the reason why. As a friend if mine once said “everything is caused by something”.
---- Fluoride depletes the energy reserves and the ability of white blood cells to properly destroy foreign agents by the process of phagocytosis. As little as 0.2 ppm fluoride stimulates superoxide production in resting white blood cells, virtually abolishing phagocytosis. Even micro-molar amounts of fluoride, below 1ppm, may seriously depress the ability of white blood cells to destroy pathogenic agents [Curnette]. Fluoride inhibits antibody formation in the blood [Jain].
----The most serious effects of all are damages to the nervous system. Fluoride synergistically with aluminum, causes nerve degeneration similar to Alzheimer’s disease. Aluminum is present in some city water, in a toothpaste tube, using aluminum pans to boil water, or drinking beverages in aluminum cans, and some baking powder. It has been found that behaviors associated with lead neurotoxicity are more frequent in communities using silicofluorides than in comparable localities that do not use these chemicals. Violent acts were up to 2 and 1/2 times higher in fluoridated communities, particularly among African Americans. He attributes this to lead levels in these criminals, which lead has its uptake enhanced by fluoride [Masters]. Rats fed amounts of fluoride similar and also slightly higher to that found in artificially fluoridated drinking water, suffered from impaired central nervous system functioning and poorer memory. There was more malaise and fatigue and significant alteration of enzyme functioning. Some researchers have concluded that there is a mechanism by which fluoride can contribute to so many neurological problems in children. Thus, links of fluoridated water to decreased intelligence in children [Lu], increased incidence of ADD and ADHD, lower cognitive ability, poorer memory and other related problems, are probably correct.
---- Varner et al found that when fluoride in water with just 1 part per million fluoride, (the amounts used for artificially fluoridated water), was used in the presence of aluminum sulfate (frequently used to improve the appearance of drinking water, present in some baking powders, and as an adjuvant in vaccines [Eisenbarth] ), the results were disastrous. Aside from brain and kidney damage, there was an eighty percent mortality rate in the animals fed doses of sodium fluoride and aluminum similar to those found in artificially fluoridated water. Animals fed the aluminum/fluoride laced water developed sparse hair and abnormal, copper-colored underlying skin which is related to premature aging. Mostly the researchers related these effects to chronic kidney failure. Further autopsy results showed serious kidney abnormalities in animals that drank water containing both sodium fluoride and aluminum fluoride. The Varner team said that “Striking parallels were seen between aluminum-induced alterations in cerebral blood vessels that are associated with Alzheimer’s disease and other forms of pre-senile dementia”. Fluoride studies in rats can be indicative of a potential for motor disruption, intelligence deficits and learning disabilities in humans. Humans are exposed to plasma levels of fluoride as high as those in rat studies. Fluoride involves interruption of normal brain development. Fluoride affects the hippocampus in the brain, which integrates inputs from the environment, memory, and motivational stimuli, to produce behavioral decisions and modify memory. Experience with other developmental neurotoxicants prompts expectations that changes in behavioral functions will be comparable across species, especially humans and rats [Muellenix] Fluorides accumulate in the brain over time to reach neurologically harmful levels [Muellenix]. If you keep rodents for pets, be sure not to give them city water.
---- It is also important that pregnant women imbibe no fluoride because it damages several brain functions and hormones in the fetuses. It also alters behavior of the babies. There is an average decline of IQ of 8 points in children showing fluorosis of the teeth. Also see this site.
----About 2 or 3% of people are especially sensitive to fluoride poisoning. Such people can not even take showers without being affected with colicky stomach and intestinal pains, severe headaches, weakness and fatigue, skin rashes, mouth ulcers, worsening of allergic conditions including wheezy breathing, blurred vision, excessive thirst and joint pains.
---- Fluoride accumulates in the pineal gland, which secretes melatonin, more than any other soft tissue in the body. The hydroxyapetite crystals in the pineal gland accumulate more fluoride than bone or teeth, up to 21,000 ppm. As a result melatonin is interfered with and this causes earlier maturation of female animals.
----At the same time there are substances that give protection to teeth, especially while children are growing, such as vitamin D, calcium, phosphate, copper and magnesium with no adverse effects in reasonable amounts and at the same time they strengthen bone [Holick]. You should be able to get all you need of these except vitamin D from unprocessed food. There are also substances present in cashew nuts and mango fruit, anacardic acids, which is very lethal to tooth cavity gram positive bacteria [Eichbaum]. Fluoride is not more lethal to cavity bacteria than conventional mouth wash [Bibby]. Fluoride does reduce solubility of enamel in acid, but only when applied topically. Eating fluoride while teeth are forming has no affect on solubility. Therefore fluoride should NEVER be given to babies or pregnant mothers or used for formula.
----I definitely recommend that you drink bottled water or collect rain water from a sanitary container if your tap water contains fluoride. This is especially important if you are on dialysis since the National Kidney Foundation has reported several deaths from fluoride in water. Cities should discontinue fluoridation because of the likelihood of future liability suits along with concern for their citizen’s health. At least legislators should insist that citizens be warned of the toxicity. 98% of European citizens now drink non fluoridated water. We should join them in the USA. Also when fluorinated water is used for irrigation, it poisons the soil for a long time. Fluoride is thought to be able to damage vegetation when the concentration is high enough, especially when boron is also high in the soil.
----Iodide can be used to increase fluoride excretion. Iodide used to be very popular with the medical profession. It was called “The Universal Medicine” over 100 years ago because it was safe, effective and had widespread applications in clinical medicine for conditions that were not responding to other treatment such as metallic poisonings, as by lead and mercury, asthma, aneurism, arteriosclerosis, angina pectoris, gout, goiter, syphilis, haemophilia, Bright’s disease (nephritis) and bronchitis. (scroll up) Iodide probably has many functions in the body other than creating thyroid hormone.
----However, after World War II, misinformation about iodide resulted in medical professionals turning against iodide. As a result, iodide has been neglected in medical textbooks and vilified in endocrine publications [Abraham 2006]. This may be part of the reason why the World Health Organization estimates that 2 Billion people, 30 percent of the world’s population, suffer from iodine deficiency disorders. More than a billion people have visible goiters and 5.7 million are cretins. An estimated additional 750 million people without goiters have undiagnosed hypothyroidism [WHO], and many millions have iodine-related mental retardation. Double the excretion of fluoride takes place if 50 milligrams of iodide/iodine as Iodoral are taken daily for one month [Brownstein][Abraham 2003]. Half again as much bromide is also excreted. It has been suggested that the symptoms of iodism is from release of bromide. Another trial showed much higher increases of bromide from supplementation with iodide. This must have been because the patient had been eating much more than normal intake of bromide added to food. I do not know if it is safe to take this much Iodoral interminably and I am apprehensive about the use of elemental iodine or iodates. since it has been used to cure hyperthyroid condition [Starr][Thompson]. However the Japanese average 14 milligrams IODIDE daily from 4.5 grams of seaweed (dried?) [Nutrition Section, Bureau of Public Health], which is 50 times the amount in the USA. In some sections the Japanese average 200 milligrams per day. A much lower breast cancer rate has been attributed to this [LeMarchand][Nagata]. Women with goiters (a visible, non cancerous enlargement of the thyroid gland) owing to iodine deficiency have been found to have a three times greater incidence of breast cancer. 15% of American women get breast cancer, as opposed to 5% 30 years ago. 90% of women have fibrocystic breast disease, sometimes painful, which can be improved with 50 milligrams of KI during the intermenstrual period [Vishniakova]. The Russian study has been replicated in the USA with similar results, but using elemental iodine.
Iodide also stimulates the immune system. Iodide has been proposed to have an affect rivaling antibiotics. It is possible that supplementation with as much as 50 milligrams of iodide per day to start would augment immunity against fungal infection, syphilis, and chronic obstructive pulmonary disease. Also see this site. Iodide also reduces the amount of insulin necessary during type I and Type II diabetes.
---- Iodide concentrations in seaweeds are as follows (milligrams. per 100 gm.); Alaria 16.6, Dulse5.2, Kelp 45.3, Laver 1.4, Hiziki 40, Arame 98-564, Kombu 193-471, Wakame 18-35, Nori .5, Rockweed 153.7, Bladderwrack 65. Potassium iodide can be purchased without a prescription from this site. The pill form contains 100 milligrams of iodide, so must be subdivided by dissolving it in a glass of water, and then drinking a portion each day. A list of wholesale suppliers of iodide is available here, although individuals may have difficulty doing business with them. Iodide is probably better than sea weed because seaweed has bromine and arsenic (22 milligrams of arsenic per 1000 grams) in it, both largely as organic compounds. Between 0.2 to 1.0 milligrams per day of arsenic is ingested by the Japanese daily. Inorganic arsenic is a risk factor for liver cancer. However hijiki seaweed has only 0.3 milligrams per 1000 grams of arsenic as arsenate, the remainder being organic, which is only mildly toxic. The UK Food Standards Agency (FSA) issued advice to consumers to avoid eating seaweeds.
----12 milligrams of iodide and iodine will also cause fluoride excretion with no adverse side effects after one month. If the body is deficient, a large percentage of iodide is retained. It is said that the retention ends when the body contains about 1500 milligrams [Abraham 2005]. It has been suggested that the only way iodide excess can produce hyperthyroid condition is if the patient has had goiter or other thyroid disease prior [Roti]. Epidemiological studies confirm that hyperthyroid is most prevalent in areas that are LOW in iodide.
----For a forum that discusses iodide access this site. For a discussion of the affect of medications on thyroid secretion or supplementation, see this site.
---- The Canadian Association of Physicians for the Environment has come out strongly in opposition to fluoridation. They maintain that decline in tooth decay is not from fluoride and that adverse effects have been underestimated.
---- Joel Kauffman has written an extensive review of the history of the political maneuvers that have foisted this poison, fluoride, on society. New hypotheses can be dangerous to the power wealth or prestige of old theory adherents [Charlton], or as Tolstoy puts it, "Most men can seldom accept even the simplest and most obvious truth if it would oblige them to admit the falsity of conclusions which they have delighted in explaining to colleagues, have proudly taught to others, and have woven thread by thread into the fabric of their lives", So it will be difficult to get this unhealthy procedure discontinued. Laws spelling out liability and setting reasonable compensations would be very desirable. If liability were removed from those organizations that advocated it because of stupidity, they would not be reluctant to come out against it. Such a law could still preserve the legal concept of “malum in se” so that any who gave such advice for evil intent would still be susceptible.
----If you should wish to see an extensive discussion of side effects of fluoride, see and Paul Connett has formed an organization devoted to getting rid of fluoride in city water and has a site giving 50 reasons for doing so. and you may see a blog devoted to persuading officials to discontinue fluoride here.
----You can see a site that has links to information on fluoride content of water in each state here.
You may see a videotape of a dentist making a passionate plea to stop fluoride poisoning here,
You may see a list of US cities that have fluoridated water.

----I have submitted a petition a few years ago to the FDA to make fluoride in tooth paste a prescription drug because of acute toxic effects if it is swallowed by children. The contents of a family-size tube of fluoridated toothpaste is enough to kill a 25-pound child. This petition was because fluoride ingestion from mouth rinses and dentifrices in children is extremely hazardous to biological development, life span and general health [Eriksson] [Augenstein]. Perhaps if you wrote in to support it the matter would be expedited. The address is; Dockets Management Branch, Food and Drug Administration, Department of Health and Human Services, Room 1-23, 12420 Parklawn Dr., Rockville, MD 20857.

REFERENCES are below. Hundreds of references are also available from Second Look’s web site. “Second Look” is an organization devoted primarily to educating people about the dangers of fluoride. An organization called “Keepers of the Well” presents arguments against fluoridation.


Any information adopted in this article you must understand is used at your own risk.

A copper deficiency has been implicated in low thyroid secretion (there are many abstracts of copper reference articles in this URL). He thinks it can be implicated in too much thyroid secretion also.

For information about how to increase potassium to prevent arthritis and heart disease, see this site.

A table, which gives copper and zinc in food per thousand Calories, is available at this site, as well as zinc/copper ratios

There is an article discussing cashew nuts to cure a tooth abscess Which might prove useful at this site.
There is also an article which proposes some speculation about diabetes. At this site.

See this site for evidence of a correlation between magnesium deficiency and cancer. The taurate is proposed as the best magnesium supplement. However, it probably only seems to be because the taurate no doubt has advantageous properties of its own in some circumstances. Taurine or 2-aminoethanesulfonic acid is an acidic chemical substance sulfonated rather than carboxylated found in high abundance in the tissues of many animals (metazoa), especially sea animals. Taurine is also found in plants, fungi, and some bacterial species, but in far less abundance. It is an amine with a sulfonic acid functional group, but it is not an amino acid in the biological sense, not being one of the twenty protein-forming compounds encoded by the universal genetic code. Small polypeptides have been identified as containing taurine, but to date there has been no report of a transfer RNA that is specifically charged with taurine [from Wikipedia]. It is essential to babies. It has been found that supplements of the amino acid, taurine, will restore the abnormal electrocardiogram present during a potassium deficiency by an unknown mechanism. This information has been used in several case histories by George Eby to control a long standing type of cardiac arrhythmia called pre atrial contractions (PACs), a benign but irritating and nerve racking heart problem, with 2,500 grams of taurine with each meal. Taurine is said to be low in the diets of vegetarians. The 2,500 milligrams recommended by the American Heart Association causes diarrhea in some people and should probably be reduced in those people. Taurine has been used for high blood pressure [Fujita], migraine headache (I suspect that less than 1000 milligrams can remove the headache caused by allergy to peanuts), high cholesterol, epilepsy, macular degeneration, Alzheimer’s disease, liver disorders, alcoholism, and cystic fibrosis, and depression. Keep in mind that some people may have a genetic defect that limits the amount of taurine tolerated and that adequate molybdenum may desirable. Taurine may make a copper deficiency worse, based on a single case history [Brien Quirk, private communication]. This may be because taurine may be mobilizing copper and zinc into the plasma [Li]. So if you should decide to take taurine, make sure your copper intake is more than adequate, as well as your zinc.

There is a site that contains reviews of natural remedies for many diseases

There is an opioid antagonist drug called Naltrexone, which stimulates the immune system to eliminate several serious diseases, including multiple sclerosis and possibly some cancers (Naltrexone in the large 50mg size, originally manufactured by DuPont under the brand name ReVia, is now sold by Mallinckrodt as Depade and by Barr Laboratories under the generic name naltrexone), that blocks some endorphin receptors. Said blockage is thought to cause the body to temporarily secrete more endorphins, especially after midnight at night. These endorphins are thought to stimulate the immune system, and in particular to stimulate the TH-1 or type 1 antiviral response by decreased interleukin-4 and with increased gamma interferon and interleukin-2 and a simultaneous decrease of type 2 anti bacterial response [Sacerdote]. It appears to be especially effective for minimizing symptoms and retarding progression of multiple sclerosis (MS) (also see these sites hereand here and this site) and. A few doctors have had encouraging results in Crohn's Disease (prompting Penn State College of Medicine to plan 4mth Study of Crohn's Disease & LDN. This has now been completed with very good results [Smith JP] ) and) CFIDS, and even to some extent in cancer. Low doses of Naltrexone (LDN), 1.5 to 4.5 milligrams, at bedtime is used (timing is important, and it is important not to buy slow release forms). It is said to have no known bad side effects at those doses other than stimulate the TH-1 or type 1 antiviral response by decreased interleukin-4 and with increased gamma interferon and interleukin-2 and a simultaneous decrease of type 2 anti bacterial response [Sacerdote]. < in two or week first the insomnia>'Case Health - Health Success Stories' website collects and shares patient testimony of success. On 'Case Health' you'll find rave reports from quite a few patients who have submitted stories to this searchable database. The present MS Access database is cumbersome and slow - you'll need to be patient. The button for the engine is on the left side and the key word "LDN" will access multiple LDN related stories. There is also reports from an extensive survey in this site. I think some clinical studies on Naltrexone are in order, and it should not be a prescription drug. Though side effects appear unlikely, it is not proven over longer periods. If you try it (it is a prescription medicine in the USA), it seems likely that you should discontinue if you get a bacterial infection in view of its inhibition of antibacterial response. Naltrexone is currently being used by Dr. Enlander, a New York City doctor, but with limited success for chronic fatigue syndrome using 3 to 4.5 milligram doses for CFIDS. . It is also being explored for AIDS by Dr. Bernard Bihari, 29 W 15th St. New York, NY 10011, 212) 929-4196 who is still prescribing Naltrexone for HIV/AIDS. (and currently Executive Director of the Community Research Initiative). Dr. Gale Guyer of Advanced Medical Center located in Zionsville, Indiana also is using it for cancer. Dr. Bihari has shown promising results for a large percentage of his cancer patients.

Olive leaf extract has shown clinical evidence of effectiveness against a wide range of viruses, including AIDS [Bihari], herpes, and cold viruses. It sometimes produces a Herxheimer or pathogen die off symptoms (from effectiveness against bacteria?). There is evidence that it is synergistic (reinforce each other) with Naltrexone. There have been a few case histories of improvement in what were probably arthritis patients and CFIDS patients. The active ingredient is said to be oleuropein or enolate. There has been very little follow up research done on it.

Also it has been found that curcumin in turmeric or curry powder will inhibit several forms of cancer, including melanoma. People who live in India where these spices are eaten, have one tenth the cancer elsewhere. Keep in mind, though, that chemicals in plants can not automatically be trusted simply because they are natural. >

A site is available which shows. foods which are high in one nutrient and low in another (including calories). This last site should be especially useful for a quick list of foods to consider first, or for those who must restrict another nutrient because of a genetic difficulty with absorption or utilization

The very extensive USDA Handbook #8 may be seen here. To access the information you must press "enter" to search, and then divide Kcal into milligrams of potassium. This last table is very comprehensive, is used in search mode, and even lists the amino acids. There are also links in it to PDF types of printouts from the table for individual nutrients available here Just click on the “A” or “W” button for the nutrient you desire.

Take a look at a marvelous site that gives average RDR multiples for most of the essential elements in graphical form from several food groups along with average costs. Vegetables are the winners. (But no copper entry)

You may find useful and easy to use a search for abstracts of medical journal references, "Gateway".
----Google’s “scholar search site” is excellent for all types of references.

The journal “Medical Hypotheses” publishes new theories in the medical field, including radical ideas.

The author, Charles Weber, has a degree in chemistry and a masters degree in soil science. He has researched copper and potassium nutrition for over 30 years, primarily a library research, as well as fluoride poison for the last year. He has published articles on allied subjects in; The Journal of Theoretical Biology (1970, 1983), The Journal of Applied Nutrition (1974), Clinical and Experimental Rheumatology (1983), and Medical Hypotheses (1984, 1999, 2007, and 2008).

The author recommends that you seek a second opinion on any medical problems from competent professionals before making any substantive changes in any of your procedures. The author does not use testimonials. While it is not the policy of this author to use testimonials, you may, if you wish, tell of the outcome of health strategies to a site which archives such experiences. Any information, including names and addresses, from readers to this author is held in confidence and not relayed to third parties, nor are cookies used. The privacy laws of the USA are followed. This site does no advertising and is funded solely by the author.

Email = isoptera at -- or 828 692 5816 (USA)


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----Abraham GE. 2004 Serum inorganic iodide levels following ingestion of a tablet form of Lugol solution: Evidence for an enterohepatic circulation of iodine. The Original Internist, 2004; 11(3):29-34.
----Abraham GE. 2005 The historical background of the Iodine Project. The Original Internist; 12(2):57-66.
---- Abraham GE. 2006 The history of iodine in medicine. Part II: The search for and the discovery of thyroid hormones The Original Internist 13(2);:67-70.
---- W.L. Augenstein WL, et al 1991 Fluoride ingestion in children: a review of 87 cases. Pediatrics 88; 907-912.
; ---- Bassin EB Wypij D Davis RB Mittleman MA 2006 Age specific fluoride exposure in drinking water and osteosarcoma (United States). Cancer Causes and Control. 17; 421-428.
---- Bibby BG Zander HA McKelleget M Labunsky B 1946 Preliminary reports on the effect on dental caries of the use of sodium fluoride in a prophylactic cleaning mixture and in a mouthwash.J Dent Res 25(4): 207-211, 1946.
----Brownstein D. 2005 Clinical experience with inorganic, non-radioactive iodine/iodide. The Original Internist 12(3):105-108. Available at:
---- Charlton BG 2008 False, trivial, obvious: Why new and revolutionary theories are typically disrespected. Medical Hypotheses 71; 1-3.
---- Pierre Galleti P Joyet G 1958 Effect of Fluorine on Thyroid Iodine Metabolism and Hyperthyroidism. Journal of Clinical Endocrinology and Metabolism. 18; 1102-1110.
---- John Curnette, et al, 1979 Fluoride-mediated Activation of the Respiratory Burst in Human Neutrophils. Journal of Clinical Investigation 63; 637-647.
----Eichbaum FW 1946 Biological properties of anacardic acid (O- pentadeca dienylsalicylic acid) and related compounds. General discussion-bactericidal action. Memorias do Instituto Butanen 19 71-86.
---- Ericsson Y Forsman B 1969 Fluoride retained from mouth rinses and dentifrices in preschool children. Caries Research 3; 290-299
----Eisenbarth SC Colegio OR O’Connor W Jr. Sutterwala FS Flavell RA 2008 Crucial role for Nalp3 inflammasone in the immunostimulatory properties of aluminum adjuvants. Nature 453; 1122-1126.
---- Emsley J, et al 1981 An unexpectedly strong bond: Ab initio calculations and spectroscopic studies of amide fluoride systems. Journal of the American Chemical Society 103; 24-28.
---- Erikson JD 1978 Mortality of Selected Cities with Fluoridated and Non-Fluoridated Water Supplies. New England Journal of Medicine 298; 1112-1116.
---- Fagin D 2008 Second Thoughts about Fluoride. Scientific American 2008, 298; 74–81.
---- Gulati P et al 1993 Studies on the leaching of fluoride in tea infusions. The Science of the Total Environment 138 (1-3); 213-221.
---- Irwin Herskowitz I Norton I 1963 Increased Incidence of Melanotic Tumors Following Treatment with Sodium Fluoride. Genetics 48; 307-310.
---- Jain SK Susheela AK 1987 Effect of Sodium Fluoride on Antibody Formation in Rabbits. Environmental Research 44; 117-125.
---- Le Marchand L, Kolonel LN, Nomura AM.1985 Breast cancer survival among Hawaiian Japanese and Caucasian women: ten-year rates and survival by place of birth.Am. J. of Epidemiol.;122:571-578.
---- Leone N, et al., 1954 Medical Aspects of Excessive Fluoride in a Water Supply. Public Health Reports 69; 925-936.
---- Lu Y, Sun ZR, Wu LN, Wang X, Lu W, Liub SS 2000 Effect of high fluoride water on intelligence in children. Fluoride 33; 74-78.
---- Masters RD and Coplan M 1998 Water Treatment with Silicofluorides and enhanced lead uptake, Fluoride, Vol. 31, No 3, Aug.
.---- Muellenix, Denbesten, Schunior, Kernan 1995 Neurotoxicity of Sodium Fluoride in Rats. Neurotoxicology and Teratology 17; 176.
---- Nagata C, Shimizu H. Risk factors for breast cancer 1996 Findings from comparative studies on Japanese in Japan, Japanese and whites in the United States. Gann Monograph on Cancer Research ;44:51-57.
----Nutrition Section, Bureau of Public Health.1964 Nutrition in Japan. Tokyo, Japan: Ministry of Health and Welfare; 1965.
Orcel P, et al 1990 Stress fractures of the lower limbs in osteoporotic patients treated with fluoride. Journal of Bone and Mineral Research 5 Suppl 1:S191-4.
----Pendrys DG Katz RV 1989 Risk of enamel fluorosis associated with fluoride supplementation, infant formula and fluoride dentifrice use. American Journal of Epidemiology 130; 1199-1208.
----Reddy GB, Arjun L. Khandare, P. Yadagiri Reddy, G. Shankar Rao, N. Balakrishna and I. Srivalli 2003 Antioxidant Defense System and Lipid Peroxidation in Patients with Skeletal Fluorosis and in Fluoride-Intoxicated Rabbits Toxicological Sciences 72, 363-368.
---- Roti E Uberti ED 2001 Iodine Excess and Hyperthyroidism. Thyroid 11(5): 493-500.
----Sharma YD, 1982 Effect of Sodium Fluoride on Collagen Cross-Link Precursors, Toxicological Letters, Vol. 10, pp. 97-100
----Starr, P., Walcott, H.P., Segall, H.N., et al, 1924 The Effect of Iodin in Exophthalmic Goiter. Arch, Int. Med., 34:355-364.
----Susheela AK and Mukerjee D, 1981 Fluoride poisoning and the Effect of Collagen Biosynthesis of Osseous and Nonosseous Tissue," Toxicological European Research, Vol. 3, No.2, pp. 99-104.
----Taylor A Taylor NC 1965 Effect of Sodium Fluoride on Tumor Growth. Proceedings of the Society for Experimental Biology and Medicine. 119; 252.
----Thompson, W.O., Thompson, P.K., Brailey, A.G., et al, 1930 Prolonged Treatment of Exophthalmic Goiter by Iodine Alone. Arch. Int. Med., 45:481-502.
----Varner, J.A., et al., 1984 Chronic administration of aluminum-fluoride or sodium fluoride to rats in drinking water: Alterations in neuronal and cerebrovascular integrity. Brain Medicine, Vol. 4, pp. 151-157.
---- Vishniakova YY, Murav’eva NI. 1966 On the treatment of dyshormonal hyperplasia of mammary glands. [Article in Russian] Vestn Akad Med Nauk SSSR 21(9):19–22.
---- Von Mundy VG 1963 Influence of Fluorine and Iodine on the Metabolism, Particularly on the Thyroid Gland," Muenchener Medicische Wochenschrift, Vol 105, pp. 182-186.
----Weisman G et al 1972 Lekocyte proteases and the immunologic release of lysosomal enzymes. American Journal of Pathology 68; 539-569.
----WHO, World Health Organization. 1996 Iodine deficiency disorders. Fact Sheet No. 121. Geneva



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